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It was suggested that tricyclic antidepressants (TCAs) may have a therapeutic or indeed prophylactic effect ().

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This is seen in clinical situations with adults who have a diagnosis of ADHD, and who are treated with stimulant medication alone.

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OCD is generally now thought to be unresponsive to psychodynamic psychotherapies, but it does respond to behaviour therapy, especially exposure and response prevention, and to medications such as clomipramine and the SSRIs ().

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The psychostimulant(s) and the anticonvulsant or anti-epileptic agent(s) may be administered according to simultaneous or alternating regimens, at the same or different times during the course of the therapy, concurrently in divided or single forms.

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The present invention provides a method of treating individuals both before and during the pre-onset phase of a serious psychiatric disorder, such as schizophrenia, schizoaffective disorder, and other associated psychoses, which may reduce or in part eliminate certain clinical features, or minimise the severity of psychotic episodes.

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One the third day the same dose was repeated with a noticeable deterioration in his ability to focus and organize his thinking.

The underlying principle of the invention is that the cognitive processes involved in the organisation, integration and prioritisation of such information is primarily potentiated or enhanced by the use of low dose anti-epileptic drug.

Particularly preferred AEDs are sodium valproate and derivatives thereof, tiagabine, topiramate, carbamazepine, oxcarbazepine, ethotoin, phenyloin, gabapentin, pregabalin, and rufinamide.

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Pitman and colleagues examined 16 TS patients, 16 OCD patients and 16 controls; results indicated that TS subjects had significantly more generalized anxiety disorder (GAD) than controls ().

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He very carefully thereafter considers the safety and sense of the combination, providing valuable guidelines for the clinician.

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As a result, the effort involved in simple tasks such as social interaction is greater than normal, as the whole interaction is compromised by the individual's attempts to suppress the intrusive thoughts.

Parkinson's disease, dementia and Mild Cognitive Impairment; addiction; reduced adherence, or non-compliance, with a medication regime; eye gaze-associated disorders, dysthymia; psychotic disorders such as schizophrenia; eating disorders such as Anorexia Nervosa and Bulimia Nervosa; sleep disorders; developmental dyspraxia; Tourette's syndrome, and personality disorders.

The continuation rate of stimulant therapy beyond 12 months, as assessed by script analysis, is frequently reported in naturalistic settings as less than 33%.

Clinical observations suggest that the core area of improvement with low dose anti-epileptic drugs appears to be in the effortless ability to sequence and organize thoughts.


By and large the author is not greatly impressed with psychological techniques for the treatment of the tics per se, as much of the documentation in the literature is anecdotal and, in her experience, results have not been particulary encouraging.

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Robertson and Stern suggest a possible clinical spectrum between TS and Sydenham's chorea, a variant of rheumatic fever with neurological involvement (); this theory is strengthened by the findings of both OCD symptoms (, ) and vocal tics () in Sydenham's chorea.

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For example, the therapeutically effective amount of co-therapy comprising administration of a psychostimulant and at least one suitable anti-epileptic agent would be the amount of the psychostimulant and the amount of the suitable anti-epileptic agent that, when taken together or sequentially, have a combined effect that is therapeutically effective.

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The most common side-effects were transient sedation and headaches ().

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A) from about 1 mg to 400 mg sodium valproate, or a derivative thereof, and from about 1 to 80 mg phenyloin and from about 1 to 200 mg dextroamphetamine sulphate; (B) from about 1 mg to 2000 mg sodium valproate, or a derivative thereof, and from about 1 to 80 mg Phenyloin and from about 1 to 200 mg dextroamphetamine sulphate; © from about 1 mg to 2000 mg sodium valproate, or a derivative thereof, and from about 1 to 80 mg Topiramate and from about 1 to 200 mg dextroamphetamine sulphate; or (D) from about 1 mg to 2000 mg sodium valproate, or a derivative thereof, and from about 1 to 80 mg Phenyloin and from about 1 to 400 mg methylphenidate.

In clinical populations such as individuals diagnosed with a psychiatric disorder the challenge of remembering to take accurately timed and appropriate dosages of medication is often a limiting factor in their general treatment, which reduces the benefit of pharmacotherapy.

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